Chemical Science & Engineering Research
Title
Synthesis, Antimicrobial Evaluation and Molecular Docking Studies of Tetrazole Containing Hybrid Levofloxacin Derivatives
Authors
T. Elavarasan,*a D.Bhakiaraj,a,b R. Jagatheesan,c M. Mathavan,d R. Sampath Kumard and M. Gopalakrishnana
Article History
Publication details: Received: 02nd March 2020; Revised: 16th March 2020; Accepted: 16th March 2020; Published: 24th March 2020
Cite this article
Elavarasan T.; Bhakiaraj D.; Jagatheesan R.; Mathavan M.; Sampath Kumar R.; Gopalakrishnan M. Synthesis, Antimicrobial Evaluation and Molecular Docking Studies of Tetrazole Containing Hybrid Levofloxacin Derivatives. Chem. Sci. Eng. Res., 2020, 2(3), 12-20.
Abstract
Synthesis of five-membered aromatic heterocyclic compounds and its derivatives is one of the most significant transformations in synthetic organic chemistry because of its much importance in pharmaceutical industry. Therefore, a greener and convenient experimental method is reported to synthesis some novel derivatives of tetrazole containing hybrid levofloxacin at ambient temperature using acetonitrile. This method results in excellent yields of tetrazole containing hybrid levofloxacin derivatives. Screening studies such as biological activities and spectral analysis are carried out and reported.
Keywords
Tetrazoles; Levofloxacin; Antibacterial; Fluroquinolone
