Title
Synthesis and Characterization of 4-Phenyl Substituted 2-Aminothiazoles Coupling Intermediate for Organic Synthesis
Authors
J. E. Ishegbe,* K. A. Bello, P. O. Nkeonye, A. A. Kogo
Department of Polymer and Textile Engineering, Ahmadu Bello University Zaria, Zaria, Nigeria
*Corresponding author E-mail address: ishegbejoyce@gmail.com (J.E. Ishegbe)
Article History
Publication details: Received: 11th March 2020; Revised: 15th April 2020; Accepted: 18th April 2020; Published: 27th April 2020
Cite this article
Ishegbe J.E.; Bello K.A.; Nkeonye P.O.; Kogo A.A. Synthesis and Characterization of 4-Phenyl Substituted 2-Aminothiazoles Coupling Intermediate for Organic Synthesis. Green Rep., 2020, 1(1), 21-26.
Abstract
A series of 4-aryl-2-aminothiazole were synthesized with an objective to develop novel and potent coupling components of synthetic origin as well as in dye synthesis. The required derivatives of 4-phenylsubstituted-2-aminothiazole were synthesized via a multicomponent condensation between thiourea, acetophenone and iodine. The intermediates were obtained using acetophenone and various substituted aldehydes to synthesize the intermediates which on cyclization with sulphur yielded the final products. Synthesized compounds were purified, characterized using UV-Visible Spectrophotometer, Infra–red, GC-MS Spectrometer and NMR. They were also evaluated for their spectra properties. All the synthesized intermediates exhibited moderate to significant properties. They were found to possess good coupling properties as well as high degree of brightness and a colour deepening effect compared to other heterocyclic couplers obtained from aniline and anthraquinone dyes.
Keywords
4-Phenyl-2-aminothiazole; green synthesis; acetophenone; heterocyclic compounds; spectral analysis
