Title
Characterization of Changes in the Ultrastructure of Neurons in the Cerebral Cortex of Rats with Subtotal Cerebral Ischemia against the Background of the Introduction of Omega-3 Polyunsaturated Fatty Acids
Authors
E.I. Bon,* N.Ye. Maksimovich, S.M. Zimatkin, O.B. Ostrovskaya, V.Yu. Smirnov and N.V. Kokhan
Grodno State Medical University, 80, Gorkogo St., 230009, Grodno, Republic of Belarus.
*Corresponding author E-mail address: asphodela@list.ru (E. I. Bon)
Article History
Publication details: Received: 07th October 2022; Revised: 31st December 2022; Accepted: 31st December 2022; Published: 05th January 2023
Cite this article
Bon E.I.; Maksimovich N.Ye.; Zimatkin S.M.; Ostrovskaya O.B.; Smirnov V.Yu.; Kokhan N.V. Characterization of Changes in the Ultrastructure of Neurons in the Cerebral Cortex of Rats with Subtotal Cerebral Ischemia against the Background of the Introduction of Omega-3 Polyunsaturated Fatty Acids. Green Rep., 2023, 4(10), 1-4.
Abstract
The aim of this study was to elucidate the ultrastructure of neurons in the parietal cortex and hippocampus of rats with subtotal cerebral ischemia against the background of the introduction of omega-3 polyunsaturated fatty acids. The neurons of the hippocampus, as a phylogenetically older part of the cerebral cortex, are less sensitive to hypoxia, which may be the reason for the therapeutic effect of Omega-3 polyunsaturated fatty acids. Thus, the administration of ω-3 polyunsaturated fatty acids has a corrective effect on the ultrastructure of hippocampal neurons under conditions of subtotal cerebral ischemia, which manifested itself in an increase in the density of mitochondrial cristae and a decrease in the density of lysosomes.
Keywords
Cerebral Ischemia; Neurons; Polyunsaturated Fatty Acids
