Title
A Comparative Cytotoxicity Evaluation of ZnO Nanoparticles against THP-1 Cells
Authors
Niraj Kumari,a Priti Kumari,a Anal K. Jhab and Kamal Prasad*c
aAryabhatta Centre for Nanoscience and Nanotechnology, Aryabhatta Knowledge University, Patna, 800001, India
bUniversity Department of Chemistry, T.M. Bhagalpur University, Bhagalpur, 812007, India
cUniversity Department of Physics, T.M. Bhagalpur University, Bhagalpur, 812007, India
*Corresponding author E-mail address: prasad_k@tmbuniv.ac.in (K. Prasad)
Article History
Publication details: Received: 25th October 2020; Revised: 20th November 2020; Accepted: 20th November 2020; Published: 30th November 2020
Cite this article
Kumari N.; Kumari P.; Jha A.K.; Prasad K. A Comparative Cytotoxicity Evaluation of ZnO Nanoparticles against THP-1 Cells. Nano Prog., 2020, 2(4), 53-57.
Abstract
Medicinal plants such as Achyranthes aspera, Phyllanthus niruri, and Azadirachta indica assisted fabrication of ZnO nanoparticles (ZnO NPs) are reported in the present work. Formations of ZnO NPs were ascertained from different characterizing tools such as X-ray diffraction, scanning, and transmission electron microscopy and UV-visible spectroscopy. A comparative study of the cytotoxic potentials of biosynthesized ZnO NPs against THP-1 cells, a human leukaemia cell lines has been undertaken. These ZnO NPs showed dose-dependent cytotoxicity against THP-1 cells by using WSA-1 assay. The results indicated that the biosynthesized especially Azardica indica mediated ZnO NPs could be utilized as a potential future therapeutic agent for cancer therapy.
Keywords
ZnO; nanomaterials; bionanotechnology; green synthesis; cytotoxicity; THP-1 cells
